MTI Biotech

How HMB Works

HMB Shifts the Balance of Protein Synthesis, Tipping the Scale in Muscle's Favor

When protein synthesis equals protein breakdown, there is no net gain of muscle protein. This is important in maintaining/increasing strength.

HMB aids in increasing muscle protein by two mechanisms. HMB decreases protein breakdown caused by intense training at a molecular level by disrupting proteolysis through the ubiquitin-proteasome proteolytic pathway, the proteolytic enzyme that breaks muscle protein down.

HMB is also a metabolite of the BCAA leucine and both have been shown to stimulate protein synthesis through the mTOR pathway.

HMB increases protein synthesis

HMB stimulates protein synthesis in muscle by multiple mechanisms, including the mTOR/p70S6k pathway, which stimulates translation initiation of protein synthesis. (Many of these effects are shared with leucine; however, HMB is more potent than leucine in promoting strength gains).

HMB decreases protein breakdown

HMB decreases protein breakdown at a molecular level caused by intense training. HMB results in decreasing the key regulating components of the ubiquitin-proteasome proteolytic pathway, which results in LESS muscle loss and damage.

Therefore, the increase in synthesis and decrease in breakdown result in greater gain of strength and faster recovery.

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