MTI Biotech

Shawn Baier August 2011 Research Update

New HMB research was presented at the Experimental Biology meeting this past April in Washington, D.C.  Experimental Biology (EB) is one of the largest multidisciplinary scientific meetings held in the US and this year approximately 13,000 scientists attended the meeting.  These scientists present cutting edge research as well as expanded research insight into known discipline areas.  Again this year new studies were presented showing how HMB works in the “real world” as well as adding to the knowledge base of how HMB works to accomplish the benefits people see in the gym.  To learn more about the Experimental Biology annual meeting, please visit http://experimentalbiology.org/EB2011Archive/content/AboutEB.aspx.

Here are the five studies on HMB that were presented at this year’s Experimental Biology meeting:

B-hydroxy- B-methylbutyrate (HMB)Supplementation and Resistance Training (RT) May Improve Body Composition and Muscle Function in Healthy Elderly Men (66–78 years): A 24-Week Study
In this study investigated the benefits of HMB consumption in elderly men some of whom were performing resistance training and some of whom did not.  The researchers found that just taking HMB improved muscle mass and function in this study.  Combine HMB with resistance training and the benefit is not only greater muscle mass and function but also greater fat loss.  In this study group the results show that regardless of how often you exercise, just taking HMB can help you improve muscle mass and strength and keep your muscles in better condition.  For more information on this study, please refer to the abstract at http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/lb230?sid=38b2c2ad-8d34-4a74-a86f-c43f3377b152

Effect of B-hydoxy- B-Methylbutyrate (HMB) and Resistance Training on Body Composition and Functionality in Elderly Women (65–89 yrs)
Similarly, elderly women were studied with some of them participating in a resistance training program and some were not.  HMB supplementation alone without resistance training resulted in increased leg strength.  Combining HMB supplementation with resistance training resulted in increased upper body muscle mass.  Again these data show that in this subject group HMB has a positive effect on muscle whether or not an exercise program is also undertaken and that combining HMB with exercise gives better results than either HMB supplementation or exercise alone.  For additional information regarding this study, read the abstract at http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/lb229?sid=38b2c2ad-8d34-4a74-a86f-c43f3377b152

β-hydroxy-β-methyl butyrate (HMB) stimulates mammalian target of rapamycin complex 1 (mTORc1) signaling via a phosphatidylinositol-3-kinase (PI3K)-dependent pathway
Studies in humans show HMB increases muscle mass.  Increasing protein synthesis in muscle is a complicated process involving many enzymatic pathways.  The more we know about these, the more we can tailor specific nutrition programs to maximize the effects on muscle mass.  This study in muscle cells grown in the laboratory showed that while both the essential amino acid leucine and the leucine metabolite HMB stimulate mechanisms of protein synthesis which increases muscle mass, they act through different mechanisms.  The end result is that to maximize benefits on muscle mass, muscle cells need a source of HMB as well as adequate protein containing essential amino acids like leucine. To find out more about his study, read the abstract at http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/1059.10?sid=38b2c2ad-8d34-4a74-a86f-c43f3377b152

β-hydroxy-β-methylbutyrate (HMB) Improves Myogenesis and Maintains Strength in Male Mice during a 6-Week Catabolic Condition
Eating a meal stimulates protein synthesis which then decreases again as the time between meals increases.  Not eating or restricting food intake for longer periods of times causes an increase in protein degradation or a catabolic state to exist.  A mouse model simulating the effect of not eating (caloric restriction causing a catabolic effect) on muscle metabolism and strength was studied.  Supplementing HMB to the mice on a caloric restricted diet was shown to increase a protein (MyoD) that is involved in muscle cell differentiation and repair.  HMB also maintained strength over the catabolic period during the study.  Therefore, HMB was shown to protect muscle during periods of catabolism caused by caloric restriction.  To learn more about this study, read the abstract at http://www.fasebj.org/cgi/content/meeting_abstract/25/1_MeetingAbstracts/1105.6?sid=38b2c2ad-8d34-4a74-a86f-c43f3377b152

β-Hydroxy-β-Methylbutyrate (HMB) Improves Body Composition and Myofiber Dimensions in Mice during Normal Physical Conditioning Not during Catabolic Conditions
In a continuation of the previous study in mice, an additional catabolic stress was induced in the mice by subjecting them to intense physical training simulating that found in soldiers in combat.  When combined with intense exercise, HMB improved body composition (increased muscle and decreased fat) and increased muscle diameter in the mice that were allowed to eat all the food they wanted; however, HMB could not overcome the extra stress and catabolic state induced by caloric restriction and intense physical training.  The results of this study show that HMB increases muscle mass and decreases fat mass during intense physical training only when combined with an adequate intake of nutrients. For more information on this study, read the abstract at


Posted on August 2, 2011


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