Wilson, J.M., R.P. Lowery, J.M. Joy, J.A. Walters, S.M. Baier, J.C. Fuller, Jr, J.R. Stout, L.E. Norton, E.M. Sikorski, S.M.C. Wilson, N.M. Duncan, N.E. Zanchi, and J. Rathmacher, 2013 β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men, Br. J. Nutr. FV:1-7
This study in trained athletes demonstrated that HMB free acid taken before a muscle-damaging, resistance-training session decreases muscle damage and improves perceived readiness to train in the next session. Thus, the athletes were able to recover quicker and train harder sooner with HMB free acid supplementation.
Dunsmore, K. A., Lowery, R. P., Duncan, N. M., Davis, G. S., Rathmacher, J.A., Baier, S.M., Sikorski, E., Morrison, T. J., Naimo, M. A., Walters, J., Wilson, S. M. C., and Wilson, J. M., 2012 Effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid gel supplementation on muscle mass, strength, and power in resistance trained individuals, J. Int. Soc. Sports Nutr. 9:Suppl. 1:P5 This is the first 12-week study using the new delivery form of beta-hydroxy-beta-methylbutyrate, HMB free acid. Highly trained athletes underwent an intense, high-volume, resistance-training program, including a 2-week overreaching phase during weeks 9 and 10. HMB free acid supplemented subjects had greater strength gains, increased Wingate power, and increased muscle thickness compared with the placebo supplemented subjects. This study showed that even in highly trained athletes, HMB free acid results in greater training gains over a 12-week periodized resistance-training program.
Sikorski, E., Wilson, J. M., Lowery, R. P., Duncan, N. M., Davis, G. S., Rathmacher, J.A., Baier, S.M.,
Naimo, M. A., Wilson, S. M. C., Dunsmore, K. A., Walters, J., Joy, J., Morrison, T. J., 2012 The acute effects of a free acid beta-hydroxy-beta-methylbutyrate supplement on muscle damage following resistance training: a randomized, double-blind, placebo-controlled study, J. Int. Soc. Sports Nutr. 9:Suppl. 1:P27 This is the first resistance training study to examine the acute effects of HMB free acid supplementation on muscle damage and perceived recovery scale (PRS) when initiating a high-volume resistance-training program. The results showed that when compared to placebo, HMB free acid resulted in decreased CPK indicating decreased muscle damage, and an increase in PRS meaning the subjects felt more recovered 48 h after the training. In conclusion, HMB free acid minimized the initial muscle damage and improved recovery in trained athletes initiating a high-volume training program.
Davis, G. S., Lowery, R. P., Duncan, N. M., Sikorski, E., Rathmacher, J.A., Baier, S.M., Morrison,
T. J., Dunsmore, K. A., Naimo, M. A., Walters, J., Joy, J., Wilson, S. M. C., and Wilson, J. M., 2012 The effects of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle damage, hormonal status, and performance following a high volume 2-week overreaching cycle, J. Int. Soc. Sports Nutr. 9:Suppl. 1:P4 The overreaching cycle during a resistance-training program is designed to simulate muscle stress that is encountered during higher intensity training, peaking for competition, or multiple-game tournaments. In this study, trained athletes underwent a 2-week overreaching cycle after 8 weeks of intense resistance-training. HMB free acid supplementation resulted in decreased CPK, an indicator of muscle damage; decreased cortisol, a stress hormone; and maintained more strength throughout the overreaching cycle. In conclusion HMB free acid provided more muscle protection against the sudden increase in training intensity compared to the placebo.
Fuller J.C., R.L. Sharp, H.F. Angus, S.M. Baier, and J.A. Rathmacher, 2011 Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt, Br. J. Nutr. 105:367-372
The results of this research study demonstrate that a liquid gel form of HMB is more readily available to tissues when taken orally than the currently available powdered form, Calcium HMB. The results show quicker and higher plasma levels of HMB with improved utilization by the tissues. HMB free acid gel could improve HMB availability and efficacy to tissues in health and disease.